Considerations like these, together with the light that superstring theories have shed upon the origins of the constants of Nature, mean that we should assess how narrowly defined the existing constants of Nature need to be in order to permit biochemical complexity to exist in the Universe , . For example, if we were to allow the ratio of the electron and proton masses ( = me /mN) and the fine structure constant to be change their values (assuming no other aspects of physics is changed by this assumption - which is clearly going to be false!) then the allowed variations are very constraining. Increase too much and there can be no ordered molecular structures because the small value of ensures that electrons occupy well-defined positions in the Coulomb field created by the protons in the nucleus; if exceeds about 5 x 10-3 2 then there would be no stars; if modern grand unified gauge theories are correct then must lie in the narrow range between about 1/180 and 1/85 in order that protons not decay too rapidly and a fundamental unification of non-gravitational forces can occur. If, instead, we consider the allowed variations in the strength of the strong nuclear force, s, and then roughly s < 0.31/2 is required for the stability of biologically useful elements like carbon. If we increase s by 4% there is disaster because the helium-2 isotope can exist (it just fails to be bound by about 70 KeV in practice) and allows very fast direct proton + proton -> helium-2 fusion. Stars would rapidly exhaust their fuel and collapse to degenerate states or black holes. In contrast, if s were decreased by about 10% then the deuterium nucleus would cease to be bound and the nuclear astrophysical pathways to the build up of biological elements would be blocked. Again, the conclusion is that there is a rather small region of parameter space in which the basic building blocks of chemical complexity can exist.
We should stress that conclusions regarding the fragility of living systems with respect to variations in the values of the constants of Nature are not fully rigorous in all cases. The values of the constants are simply assumed to take different constant values to those that they are observed to take and the consequences of changing them one at a time are examined. However, if the different constants are fully linked together, as we might expect for many of them if a unified Theory of Everything exists, then many of these independent variations may not be possible. The consequences of a small change in one constant would have further necessary ramifications for the allowed values of other constants. One would expect the overall effect to be more constraining on the allowed variations that are life-supporting. For examples of such coupled variations in string theories see refs. [29, 30, 31].
These considerations are likely to have a bearing on interpreting any future quantum cosmological theory. Such a theory, by its quantum nature, will make probabilistic predictions. It will predict that it is ``most probable'' that we find the universe (or its forces and constants) to take particular values. This presents an interpretational problem because it is not clear that we should expect the most probable values to be the ones that we observe. Since only a narrow range of the allowed values for, say, the fine structure constant will permit observers to exist in the Universe, we must find ourselves in the narrow range of possibilities which permit them, no matter how improbable they may be , . This means that in order to fully test the predictions of future Theories of Everything we must have a thorough understanding of all the ways in which the possible existence of observers is constrained by variations in the structure of the universe, in the values of the constants that define its properties, and in the number of dimensions it possesses.
I would like to thank Professor Elio Sindoni and Donatella Pifferetti for their efficient organisation and kind hospitality in Varenna and Paul Davies, Christian de Duve, Mario Livio, Martin Rees, and Max Tegmark for helpful discussions on some of the topics discussed here. The author was supported by a PPARC Senior Fellowship.