The distribution and gravitational stability of a ring galaxy's ISM changes dramatically as it evolves. Further, the long confinement in the dense star forming ring is expected result in a fragmented and largely atomic ISM, which may explain the peculiar star formation laws, efficiencies, and fmol observed in the two largest and most evolved ring galaxies, Cartwheel and L-S. Future progress will require sensitive and high resolution assays of the molecular ISM in these and other ring galaxies, which will be possible with ALMA and CARMA.